Radial Distribution Function for Semiflexible Polymers Confined in Microchannels

An analytic expression is derived for the distribution $G(\vec{R})$ of the end-to-end distance $\vec{R}$ of semiflexible polymers in external potentials to elucidate the effect of confinement on the mechanical and statistical properties of biomolecules. For parabolic confinement the result is exact whereas for realistic potentials a self-consistent ansatz is developed, so that $G(\vec{R})$ is given explicitly even for hard wall confinement. The theoretical result is in excellent quantitative agreement with fluorescence microscopy data for actin filaments confined in rectangularly shaped microchannels. This allows an unambiguous determination of persistence length $L_P$ and the dependence of statistical properties such as Odijk's deflection length $\lambda$ on the channel width $D$. It is shown that neglecting the effect of confinement leads to a significant overestimation of bending rigidities for filaments

One dimensional Si-in-Si(001) template for single-atom wire growth

Single atom metallic wires of arbitrary length are of immense technological and scientific interest. We describe a novel silicon-only template enabling the self-organised growth of isolated micrometer long surface and subsurface single-atom chains. It consists of a one dimensional, defect-free reconstruction - the Haiku core, here revealed for the first time in details - self-assembled on hydrogenated Si(001) terraces, independent of any step edges. We discuss the potential of this Si-in-Si template as an appealing alternative to vicinal surfaces for nanoscale patterning.Comment: 3 pages, 2 figure

Dynamical constraints on some orbital and physical properties of the WD0137-349 A/B binary system

In this paper I deal with the WD0137-349 binary system consisting of a white dwarf (WD) and a brown dwarf (BD) in a close circular orbit of about 116 min. I, first, constrain the admissible range of values for the inclination i by noting that, from looking for deviations from the third Kepler law, the quadrupole mass moment Q would assume unlikely large values, incompatible with zero at more than 1-sigma level for i 43 deg. Then, by conservatively assuming that the most likely values for i are those that prevent such an anomalous behavior of Q, i.e. those for which the third Kepler law is an adequate modeling of the orbital period, I obtain i=39 +/- 2 deg. Such a result is incompatible with the value i=35 deg quoted in literature by more than 2 sigma. Conversely, it is shown that the white dwarf's mass range obtained from spectroscopic measurements is compatible with my experimental range, but not for i=35 deg. As a consequence, my estimate of $i$ yields an orbital separation of a=(0.59 +/- 0.05)R_Sun and an equilibrium temperature of BD of T_eq=(2087 +/- 154)K which differ by 10% and 4%, respectively, from the corresponding values for i=35 deg.Comment: LaTex2e, 11 pages, 3 figures, no tables. It refers to gr-qc/0611126 and better clarify the result obtained there. Accepted by Astrophysics and Space Scienc

Measurement of the β\beta-asymmetry parameter of 67^{67}Cu in search for tensor type currents in the weak interaction

Precision measurements at low energy search for physics beyond the Standard Model in a way complementary to searches for new particles at colliders. In the weak sector the most general $\beta$ decay Hamiltonian contains, besides vector and axial-vector terms, also scalar, tensor and pseudoscalar terms. Current limits on the scalar and tensor coupling constants from neutron and nuclear $\beta$ decay are on the level of several percent. The goal of this paper is extracting new information on tensor coupling constants by measuring the $\beta$-asymmetry parameter in the pure Gamow-Teller decay of $^{67}$Cu, thereby testing the V-A structure of the weak interaction. An iron sample foil into which the radioactive nuclei were implanted was cooled down to milliKelvin temperatures in a $^3$He-$^4$He dilution refrigerator. An external magnetic field of 0.1 T, in combination with the internal hyperfine magnetic field, oriented the nuclei. The anisotropic $\beta$ radiation was observed with planar high purity germanium detectors operating at a temperature of about 10\,K. An on-line measurement of the $\beta$ asymmetry of $^{68}$Cu was performed as well for normalization purposes. Systematic effects were investigated using Geant4 simulations. The experimental value, $\tilde{A}$ = 0.587(14), is in agreement with the Standard Model value of 0.5991(2) and is interpreted in terms of physics beyond the Standard Model. The limits obtained on possible tensor type charged currents in the weak interaction hamiltonian are -0.045 $< (C_T+C'_T)/C_A <$ 0.159 (90\% C.L.). The obtained limits are comparable to limits from other correlation measurements in nuclear $\beta$ decay and contribute to further constraining tensor coupling constants

Confirmation of Parity Violation in the Gamma Decay of 180Hfm^{180}Hf^{m}

This paper reports measurements using the technique of On Line Nuclear Orientation (OLNO) which reexamine the gamma decay of isomeric $^{\rm 180}$Hf$^{\rm m}$ and specifically the 501 keV 8$^{\rm -}$ -- 6$^{\rm +}$ transition. The irregular admixture of E2 to M2/E3 multipolarity in this transition, deduced from the forward-backward asymmetry of its angular distribution, has for decades stood as the prime evidence for parity mixing in nuclear states. The experiment, based on ion implantation of the newly developed mass-separated $^{\rm 180}$Hf$^{\rm m}$ beam at ISOLDE, CERN into an iron foil maintained at millikelvin temperatures, produces higher degrees of polarization than were achieved in previous studies of this system. The value found for the E2/M2 mixing ratio, $\epsilon$ = -0.0324(16)(17), is in close agreement with the previous published average value $\epsilon$ = - 0.030(2), in full confirmation of the presence of the irregular E2 admixture in the 501 keV transition. The temperature dependence of the forward-backward asymmetry has been measured over a more extended range of nuclear polarization than previously possible, giving further evidence for parity mixing of the 8$^{\rm -}$ and 8$^{\rm +}$ levels and the deduced E2/M2 mixing ratio.Comment: 28 pages, 9 figures, accepted for publication in Physical Review

Mise au point d'un nouveau modèle de comportement élasto-viscoplastique. Application au dimensionnement à la fatigue d'un collecteur d'échappement de moteur Diesel en fonte

National audienceFatigue design of structures for high temperature service resorts to modelling based on elasto-viscoplasticity constitutive laws. The new model describes complex anisothermal cyclic loadings, accounting for viscosity on a large range of strain. The new constitutive law that has been developed for nodular cast iron, is intended for the design of automotive parts for high temperature service

Détermination d'une nouvelle loi de comportement élasto-viscoplastique pour une fonte à graphite sphéroidal. Application au dimensionnement à la fatigue oligocyclique d'un collecteur d'échappement de moteur diesel automobile

National audienceLe travail présenté ici porte sur le développement d'une nouvelle loi de comportement mécanique élastoviscoplastique. Cette dernière est développée dans le but de dimensionner à la fatigue thermomécanique des structures de l'industrie automobile travaillant à hautes températures en décrivant au mieux la viscosité sur une large gamme de sollicitation. Ce nouveau modèle a été implémenté dans le code Abaqus en se basant sur l'algorithme du retour radial. Des simulations thermomécaniques ont été ensuite réalisées sur des collecteurs d'échappement et ont permis de prédire la tenue dimensionnelle ainsi que les zones à risque du point de vue fissuration

CLIP and complementary methods

RNA molecules start assembling into ribonucleoprotein (RNP) complexes during transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA, coordinates all processes in which the RNA is involved. To identify the sites bound by a specific RNA-binding protein on endogenous RNAs, cross-linking and immunoprecipitation (CLIP) and complementary, proximity-based methods have been developed. In this Primer, we discuss the main variants of these protein-centric methods and the strategies for their optimization and quality assessment, as well as RNA-centric methods that identify the protein partners of a specific RNA. We summarize the main challenges of computational CLIP data analysis, how to handle various sources of background and how to identify functionally relevant binding regions. We outline the various applications of CLIP and available databases for data sharing. We discuss the prospect of integrating data obtained by CLIP with complementary methods to gain a comprehensive view of RNP assembly and remodelling, unravel the spatial and temporal dynamics of RNPs in specific cell types and subcellular compartments and understand how defects in RNPs can lead to disease. Finally, we present open questions in the field and give directions for further development and applications